Health Informatics & Interoperability Lead (Remote Eligible)

Mathematica

Ann Arbor, MI Posted October 15, 2026

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On-site Full-time Mid level
Job Description

Mathematica seeks a Health Informatics Interoperability Lead to provide strategic, technical, and subject matter leadership across health information interoperability, health informatics, digital health, clinical quality measurement and improvement, and value-based care initiatives.

This individual will help shape and advance Mathematica’s interoperability and Fast Healthcare Interoperability Resources (FHIR) strategy and capabilities and provide senior-level guidance to multidisciplinary teams working at the intersection of health policy, clinical data, health information technology, quality measurement, data standards, and technology.

The Health Informatics Interoperability Lead will work across a diverse portfolio of federal, state, and other health care initiatives focused on modernizing health data infrastructure, improving the exchange and use of health information, advancing digital quality measurement, and strengthening data-driven health care delivery and public health.

Clients and partners include agencies within the U.S. Department of Health and Human Services, such as the Centers for Medicare Medicaid Services (CMS), as well as state health and public health agencies and other organizations across the health care ecosystem. The Health Informatics Interoperability Lead will bring deep expertise in health information technology standards, interoperability frameworks, clinical and administrative data, terminology and coding, and the exchange and use of health information across systems.

This individual will apply technical and strategic knowledge of FHIR, HL7 standards, implementation guides, application programming interfaces (APIs), health information exchange, clinical data models, terminology standards, and related technologies to support interoperable data solutions across a range of health care use cases (including public health). The role will also provide thought leadership and oversight in digital quality measurement and related interoperability applications, including FHIR-based quality measurement, electronic clinical quality measures, and clinical decision support.

The individual will lead and mentor technical staff, contribute to business development and capability building, and represent Mathematica with clients, partners, and national standards and interoperability communities. As a senior leader in a growing area of Mathematica’s portfolio, this individual will help identify and shape new opportunities, strengthen Mathematica’s interoperability capabilities, and will apply interoperability expertise across existing and emerging projects. This opportunity is available on either a full- or part-time basis.

Core Responsibilities

  • Serve as a senior health informatics and interoperability subject matter expert to internal project teams and external clients and stakeholders, providing strategic and technical leadership across[KP1][KB2] FHIR, health data standards, health information exchange, EHR-enabled solutions, digital quality measurement, interoperable analytics, and possibly clinical decision support.
  • Lead and advance Mathematica’s interoperability and FHIR strategy, including strategic planning, technical architecture and approaches, standards alignment, capability development, implementation strategy, and positioning for future client needs.

Provide technical leadership on projects and initiatives involving interoperable health data and digital quality measurement, including:

  • Electronic clinical quality measures, FHIR-based measures, and quality reporting FHIR resources, profiles, implementation guides, APIs, terminology standards, data models, and other HL7 standards CQL, QDM, QRDA, value sets, and measure development and implementation tools Interoperability implementation, testing, validation, and data quality Guide the translation and exchange of clinical, administrative, quality, and other health care data across EHRs, health information systems, data platforms, analytic environments, and other technology ecosystems.
  • Guide interoperability implementation, testing, validation, conformance, data quality, terminology mapping, and alignment with applicable standards and implementation guides.
  • Translate and synthesize policy, regulatory, clinical, technical, operational, and business requirements into interoperability strategies, technical specifications, implementation guidance, solution designs, analytic approaches, and recommendations for project teams and clients.
  • Work with current and prospective clients to understand their strategic goals, workflows, data environments, technology ecosystems, interoperability challenges, and technical needs and develop appropriate approaches and solutions.
  • Contribute to business development and growth by identifying emerging client needs and opportunities, developing technical and solution strategies, contributing to proposal and capture activities, and participating in client presentations and discussions.
  • Mentor, coach, and provide technical oversight to staff working across health informatics, interoperability, digital quality measurement, clinical data, and related technical projects.
  • Represent Mathematica in national meetings, standards development activities, technical expert panels, client forums, HL7 community activities, and other health informatics, interoperability, and quality measurement venues.
  • Provide consultation and training internally on interoperability standards and practices, FHIR strategy and implementation, health information exchange, clinical data standards, digital quality measurement, and emerging health informatics practices.
Required Skills
leadership business development electronic health records strategic planning testing
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